Serotonergic dysfunction and aggression control
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چکیده
In the early seventies we reported the occurrence of diminished post-probenecid accumulation of 5hydroxyindoleacetic acid (5-HIAA) in cerebrospinal fluid (CSF) in depression (van Praag el al. 1970; van Praag & Korf, 1971). Lowered baseline and post-probenecid 5-HIAA levels in CSF are an indication of diminished metabolism of the mother amine serotonin (5-hydroxytryptamine, 5HT) in the CNS. Low CSF 5-HIAA appeared not to be related to a particular syndromal depression type, though the phenomenon occurred more frequently in vital (endogenous, melancholic) depression than in personal (neurotic, dysthymic) depression (van Praag et al. 1965); more frequently in severe than in mild depression, and more frequently in psychotic than in non-psychotic depression.
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